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BIOACTIVITIES OF COW URINE AND ITS ARKA (DISTILLATE) FOR UTILITY IN AGRICULTURE AND HEALTH

 

In an attempt to utilize farm and cattle shed waste, a process has been developed wherein distillation waste (plant herbage after distillation) and cow’s urine were used for production of vermicompost. It has been observed that addition of cow’s urine in composting pits led to production of superior quality vermicompost with higher concentrations of major macro- and micro-nutrients. Such vermicompost was found to be superior in terms of useful microflora (fungi, bacteria and actinomycetes). Application of this vermicompost in pots significantly improved the yields of leucerne (Medicago sativa) when compared with pots supplemented with vermicompost produced without using cow’s urine.

Cow urine has been described in ‘Sushrita Samhita’ and ‘Ashtanga Sangraha’ to be the most effective substance/secretion of animal origin with innumerable therapeutic values. In Ayurveda cow urine is suggested for improving general health. However the biological activity of the cow urine has not been proven scientifically. 

Researchers at CIMAP have identified a cow urine distillate fraction as a bioenhancer of commonly used antibiotics and anti-cancer drugs. Bioenhancers are substances, which do not possess drug activity of their own but promote and augment the bioactivity or bioavailability or the uptake of drugs in combination therapy. Such bioenhancers have been earlier isolated only from plant sources. In our study we found that ‘cow urine distillate fraction’ enhances the activity of antibiotics such as rifampicin by about 5-7 folds against E.coli and 3-11 folds against Gram-positive bacteria. Rifampicin is a front-line anti-tubercular drug used against tuberculosis. Interestingly, it was also found that ‘cow urine distillate fraction’ enhanced the potency of ‘Taxol’ (paclitaxel) against MCF-7 a human breast cancer cell line in in-vitro assays (US Patent No.6,410,059) 

BIO ENHANCEMENT OF DRUGS AND NUTRIENTS BY ‘GO-MUTRA’ AND ITS DRY FRACTION

 

Classes of Drugs

Effective Conc.

(mg/ml)

Folds enhancement of bioactivity observed

‘Go-Mutra’

‘Go-Mutra’ filtered

Ammonium hydroxide (for pH balance)

Purified fraction

(CIM 1998)

I. Antibiotics & Antimycobacterials

Ampicillin

Rifampicin

Isoniazid

 

 

0.1 - 8.0

0.05 - 30

0.01 - 125

 

 

5.0

7.1

7.5

 

 

5.0

6.8

7.0 

 

 

Nil

Nil

Nil

 

 

5.8

8.2

6.5

II. Anti-cancer

Taxol

 

0.001-0.01

 

5.5

 

5.0

 

Nil

 

5.0

III. Anti-fungal

Clotrimazole

 

 

0.01 – 4.5

 

 

2.5

 

 

3.0

 

 

Nil

 

 

5.0

IV. Uptake and adsorption assays

Transformation

Phage adsorption

 

 

 

2.5

3.1 

 

 

2.3

2.5

 

 

0.2

0.3

 

 

-

-

V. Vitamins

Cyanocobalamine

 

100 - 1000

 

2.5

 

-

 

-

 

 

Central Institute of Medicinal and Aromatic Plants

P.O. CIMAP, Lucknow – 226 015

 
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